ELEVATED PLASMA RENIN ACTIVITY AND “BIG RENIN” IN MESOBLASTIC NEPHROMA

Congenital mesoblastic nephroma.

Congenital mesoblastic nephrorna (CMN) is a rare lesion but in the neonatal age group is second only to sacroccygeal teratoma. It is thought to be variant of Wilms tumour that also arises from primitive renal cells. Molecular characterisation and pattern of gene expression suggests that different factors are involved in the pathogenesis of these two tumours. CMN is generally a benign tumour alt...

Direct renin assay and plasma renin activity assay compared.

substances produced an interference 5% compared with the serum diluted with drug cocktail diluent. The list of drugs tested appears in Supplement 1, which accompanies the online version of this Technical Brief at http:// www.clinchem.org/content/vol50/issue11/. Ion suppression was assessed as recommended by Annesley (12 ). Briefly, the response of calibrators injected into the mobile phase was ...

Sample requirements for plasma renin activity and immunoreactive renin.

Plasma renin activity and plasma prorenin assays.

Sensitivity and accuracy are essential features of an assay of plasma renin activity (PRA) because the normal concentration of PRA is only 1 pmol/L, and subnormal concentrations have diagnostic relevance. Conditions for blood collection need to be standardized but the conditions are not difficult for outpatients. For routine diagnostic purposes blood should be collected from ambulatory (ideally...

Determinants of Plasma Renin Activity

The plasma renin activity (PRA) is affected by a number of environmental factors. However, significant heritability has been shown for the activity. A hypothesis that a candidate regulatory single-nucleotide polymorphism, C-5312T, of human renin gene should have a significant effect on PRA was elucidated and updating of independent determinants of PRA was attempted. Cross sectional study.